Kepel (Stelechocarpus burahol) fruit used to prevent a pregnancy by princess palace, but there has been no scientific evidence. This study was conducted to determine the effects of kepel fruit extracts on ovarian histology and endometrial thickness. Ten female Balb/C mice were used in this study and randomly divided into two groups: group 1 as control (n = 5) was treated water and group 2 (n = 5) was treated with kepel fruit extract on dose 65 mg/kg BB BB for 14 days. All animals were sacrificed by decapitation to obtain ovaries for histological examination and uterus for endometrial thickness. Independent Sample T-Test analysis was used and statistical significance was defined as p < 0.05. Histopathologic evaluation of ovaries showed that ovaries from the control group have the mean number of primary, secondary, and de Graaf’s follicles were 11.40 ± 5.18, 12.60 ± 4.67, 6.60 ± 1.14, respectively. On the group 2, the mean number of primary, secondary, and de Graaf’s follicles were 20.25 ± 9.18, 20.25 ± 6.75, 7.50 ± 2.08, respectively. There was no difference in each folicles number variables between groups (p > 0.05). The endometrial thicknes in the kepel fruit extract group (695.96 ± 252.70 μm) was higher than control group 582.70 ± 120.52 μm), but there was no significantly difference (p=0.401). The results of this experimental mice model suggest that the treatment of kepel fruit extract on dose 65 mg/kg BB affect ovarian histology and endometrial thickness, but not significant.

Keywords: Kepel fruit extracts, primary follicle, de Graaf’s follicle, secondary follicle, ovarian histology, endometrial thickness