The study focus the development learning material on the material respiration and digestion. The purpose of this study was obtain a valid learning material then practical and effective learning. The research is development research with four-D models. The population in this study were elementery school students of SD Negeri Banjarsari 1, SD Negeri Banjarsari 2, and SD Negeri Kalisari 3 at 5th class. The variables of the material validation, multimedia validation, the response of teachers respons of students‘, and students test. The average value validator of interactive multimedia 3.82 so that the study was supported to be valid. The positive response of students‘ interest in learning to follow and teachers gave very good comments, the teaching-learning device is so practical to used. Resulted of class control has mean 67.25 and experiment class has mean 81.75. Thus, interactive multimedia was effective.