Stress factors have been caused immunological reactions that have been impacted on the disease. Previous study concluded that adaptation to environment surround through mechanism immune response, so conditions of cognitive stressors nurses performed with a refreshing mechanism through training for nurses. Study aims known correlation between dhikr intervention and increasing immunology for nursing. Study design were used time series intervention. Intervention was given for 3 week through three method intervention such teaching, guiding and environment. Research with level of significant 99% CI. Based on formula was calculated 35 samples. Data were analyzed with paired t test. Between three method intervention that environment method is domain highly score for intervention. Differences between pre and post intervention score for dhikr is significant t = -2.808; p = 0.008. Significant differences between before and after dhikr intervention for IgG. Dhikr intervention was significantly increasing of IgG levels for nurses in Sultan Agung Hospital.