The transmission of HIV/AIDS in Indonesia is growing fast. One of the triggers is risky sexual behaviors done by prostitutes and their customers. This study is aimed at obtaining in-depth understanding of the efforts made by prostitutes in preventing the contagious disease of HIV/AIDS in Semarang city. The method used in this study was qualitative design with phenomenology approach. There were 8 participants involved and were selected by using purposive sampling technique. The data were collected by using in-depth interview technique with semi-structured questions, while the data analysis was carried out based on Colaizzi steps. The results of the study are divided into 3 themes: obtaining information from health professionals, optimizing the available health facilities, and the consistency of condom use. The study concludes that the participants are able to recognize the risk of disease threatening their health so that they obey the advice given by health professionals to diligently do health screening and try to use condom when serving the guests. The study suggests that it is important to strengthen the commitment of the prostitutes to obey the advice given by health professionals.