The inmates (WBP) with murder case in class I penitentiary of Semarang generally get depression. This leads to this study with narima ing pandum (NIP) intervention. The treatment employed local wisdom approach to accommodate individual values that the inmates believe. This study aims to prove empirically the effect of narima ing pandum (NIP) intervention on murder case inmates’ depression. To investigate the level of depression before and after the training, scale Beck Depression Inventory (BDI) was employed. The materials given in this training are opening, opening the WBP's insights, managing attitudes, let's be thankful, let's be patient, let's narima, and identifying the purpose of life. The intervention employed an experimental method with pretest-posttest control group design. The participants were 12 WBP murder cases who were grouped into experimental groups and control groups. The results of the analysis showed that NIP group intervention can decrease the depression score more in the experimental group than the control group. The results of this study can be used by the Prison as alternative solution in overcoming the psychological problems of WBP and in addition to the study of indigenous research in dealing with the impact of crime.