The aim of this study is to analyze the impact of digital work design on social relationship skill through Digital-Mediated Communication (DMC) for learning methods in the digital era. This study presents how to improve social relationship skill for university lectures. Data were collected by using questionnaire techniques with SmartPLS as the analysis tool. The result found that all hypotheses are confirmed. The Implementation of DMC not only improves social relationship skill but also improve the virtual empathy that rarely appear during digital interaction. The model of social relationship skill improvement through DMC and digital work design can be used by researchers and practitioners to study and achieve the future in various organizations