The purpose of this study was to examine attitudes towards computer-based learning materials, and lecture-student learning interaction as predictor self-regulated learning. One hundred and nine of college student of economics faculty in Sultan Agung Islamic University of Semarang majoring Management and Accounting participated in this study. students were devide in tree period of study ; 38 student with one-year period of study, 33 students with two years period of study and 38 students with three years period of study. The way the subject choosen in this research with unproportional stratified random sampling procedure. The device used in this study are scales and documentation, which there are three type of scale that is : motivated strategies for learning questionnaire, attitude towards computer-based learning materials scale and lecturer-student learning interaction scale and documentation about period sof study. The statistical model to test the hypothesis used in this study is multiple regression analysis with two predictor. Results of this study showed that: a) there a relationship with attitudes towards computer-based learning materials, and lecturer-student interaction with selfregulated learning, by regression coefficient (R) = 0.528 and p=0.000 (p<0,05), effective contribution of two predictor are 26.5% by F value of 20.504, b) there are positive correlation between attitudes towards computer-based learning materials with self-regulated learning, by r1-2 = 0.334 and p=0.000 (p<0.05), d) there are positive correlation between lecture-student learning interaction with self-regulated learning, by r2-1 = 0.319 and p=0.001 (p<0.05). based on the results of this study, attitudes towards computer-based learning materials and lecture-student learning interaction is effective predictor on self-regulated learning. Based on those findings we suggest that the introduction of an orientation program on campus learning media and learning methods, especially related to student faculty interaction necessary for new students. Beside it educational institutions managers need to equip teachers with the ability to provide support and ability to facilitate active learning process.