Human-Technology Interaction (HTI) is an intensive interaction between humans and technology to achieve organizational goals. In the digital era, the interaction between humans and technology is becoming more massive due to its efficient and effective ways to meet the work requirements. Therefore, redesigning the business model through the Human-Value orientation is needed. Human value orientation applies to the principle that welfare, health and humanities are priorities in running a business. The human ecosystem in the organization consisting of customers, workforce, and partners becomes the new focus of business strategy. Human comfort and welfare are a top priority, even though it must coexist with the obstacles and take advantage of advances in information technology. The ability to unite to improve the collective capabilities of human resources and the use of technology will provide significant changes for business sustainability. This paper presents several methods and techniques for implementing the transformation model with the human value orientation approach.