Background: Porang glucomanan has been shown to have a potential properties for the prevention of Metabolic Syndrome (MetS). This study aimed to investigate that porang glucomannan supplementation can improve lipid profile in metabolic syndrome induced rats.

Methods: Thirty male Sprague-Dawley rats were randomly divided into 5 groups consisting a contol group standard diet (Normal); metabolic syndrome group (SM), metabolic syndrome group + 25mg/200gBW porang glucomannan (GMP25), metabolic syndrome group + 50mg/200gBW porang glucomannan (GMP50), and metabolic syndrome group + 100mg/200gBW porang glucomannan (GMP100). The lipid profile before and after induction with high-fat and high-carbohydrate diet, and after 28 days of porang glucomannan supplementation were evaluated. Data were analyzed using One Way Anova followed by LSD Post Hoc test.

Results: GMP100 group showed the highest reversal of diet-induced changes, with decreased total cholesterol (TC), triglycerides (TG), and LDL, and also increased HDL level. The mean levels of TC, TG, and LDL in GMP100, GMP50 and GMP25 was significantly lower than those of in SM (p = 0.000), and was significantly higher than those of normal (p = 0.000). While the levels of HDL in GMP 100, GMP50, and GMP25 was significantly higher than those of SM (p = 0.000), but significantly lower than those of normal (p = 0.000).

Conclusion: Porang glucomannan supplementation improves lipid profile in metabolic syndrome induced rats with best dose at 100 mg/200 gBW.

keywords: Glucomannan, Lipid Profile, Metabolic Syndrome, Porang