Concerning the "black box" on the relationship between leadership and performance, this study aimed to examine the effect of transglobal Islamic leadership (ITL) on human resources (HR) performance mediated by meaningful work, employee engagement, and creativity. This research was conducted on 152 lecturers and educational staff of Islamic Higher Education (IHE) in Central Java, Indonesia. The data collected from the survey was applied to structural equation modeling (SEM) using AMOS. From the study, it was found that ITL significantly affects meaningful work, employee engagement, and HR performance; meaningful work significantly affects employee engagement, creativity, and HR performance; employee engagement significantly affects creativity, but does not significantly affect HR performance; while creativity significantly affects to HR performance. This study contributed to the literature regarding the role of ITL, meaningful work, employee engagement, and creativity in creating HR performance. The originality of this study is to offer an ITL style; ITL affects HR performance mediated by meaningful work, employee engagement, and creativity. Thus, there is no research has investigated such causality.