Abstraks Folic acid is a vitamin B (B9) part of the vitamin B complex that can be isolated from green leaves (like spinach), fresh fruit, skin, liver, kidney and yeast. In the synthesis of folic acid when consumed by the body and converted by enzymes to dihidrofolate reduktasedihidrofolate dissolved in water and them formed into a bond tetrahidrofolat, folate groups that play a role in the formation of the DNA in the process in the formation erithropoesis the red blood cells or erythrocytes (cell grains red) and the development of the nervous system. In normal circumstances, the body requires 50 micrograms of folic acid. If a day of folic acid absorbed less than 50 micrograms, than in four month will be exposed to folic acid deficiency. The need to increase folic acid during pregnancy can be up to 800 micrograms to 1 milligrams per day. Besides folic acid also increased in infants, children and adolescents and in people with certain diseases, such as cancer and some skin diseases. Folic acid deficiency is very influential in the development of the nervous system of primary brain and spinal cord causing fetal neural tube defect. folic acid plays an important role in the early phases at the formation of the fetus. If the deficiency can occur Spina bifida, anencephaly, Encephalocele.